李扬，博士，硕士生导师

地址：湖北武汉东湖新技术开发区光谷一路206号，武汉工程大学化工与制药学院

邮编：430205

Email: lyyy9281015@163.com

教育背景

2017/09-2022.06，武汉大学，药学，博士

2013/09-2017/06，武汉工程大学，制药工程，学士

工作履历

2024/08-至今，武汉工程大学，未定级；

2022/07-2024/07，华东理工大学，博士后；

科研项目

1. 国家自然科学基金青年项目，22307036，30万，主持

2. 中国博士后科学基金面上项目，2023M731079，8万，主持

3. 上海市超级博士后资助项目，2022161，30万，主持

4. 武汉工程大学科学基金，10万，主持

研究领域

药物化学：诊疗探针与药物递送

化学生物学：光学探针（如荧光和磷光探针等）与生物成像/传感

精细化工：有机功能染料（如近红外荧光与有机室温磷光材料等）

代表性论文：

[1] Yang Li; Zhiqin Wu; Zizhao Huang; Chenjia Yin; He Tian; Xiang Ma*. Activatable red/near-infrared aqueous organic phosphorescence probes for improved time-resolved bioimaging. National Science Review, 2024, nwae383.

[2] Yang Li, Jianfeng Gao, Shuping Wang, Mingxia Du, Xiaowen Hou, Tian Tian, Xue Qiao, Zhiquan Tian, Peter J. Stang*, Shijun Li*, Xuechuan Hong*, Yuling Xiao*. Self-assembled NIR-II fluorophores with ultralong blood circulation for cancer imaging and image-guided surgery. Journal of Medicinal Chemistry, 2022, 65, 2078–2090.

[3] Yang Li, Jianfeng Gao, Shuping Wang, Shijun Li, Xiaowen Hou, Yanna Pan, Jialu Gao, Xue Qiao, Zhiquan Tian, Deliang Chen, Hai Deng, Zixin Deng, Xuechuan Hong, Yuling Xiao*. Organic NIR-II dyes with ultralong circulation persistence for image-guided delivery and therapy. Journal of Controlled Release, 2022, 342, 157-169.

[4] Yang Li, Hua Zhu, Xiaobo Wang, Yan Cui, Lijuan Gu, Xiaowen Hou, Mengting Guan, Junzhu Wu, Yuling Xiao, Xiaoxing Xiong*, Xianli Meng*, Xuechuan Hong*. Small-molecule fluorophores for NIR-IIb imaging and image guided therapy of vascular diseases. CCS Chemistry, 2022, 4, 3735–3750.

[5] Yang Li, Yufang Liu, Qianqian Li, Xiaodong Zeng, Tian Tian, Wenyi Zhou, Yan Cui, Xikun Wang, Xiaoding Cheng, Qihang Ding, Xiaofei Wang, Junzhu Wu, Hai Deng, Yanqin Li, Xianli Meng, Zixin Deng, Xuechuan Hong and Yuling Xiao*. Novel NIR-II organic fluorophores for bioimaging beyond 1550 nm. Chemical Science, 2020, 11, 2621-2626.

[6] Yang Li, Qiao, X., Hong, X. A bright NIR-II fluorescence probe for vascular and tumor imaging. Journal of Visualized Experiments, 2023, e64875.

[7] Yishen Liu, Yang Li, Seyoung Koo, Yao Sun, Yixuan Liu, Xing Liu, Yanna Pan, Zhiyun Zhang, Mingxia Du, Siyu Lu, Xue Qiao, Jianfeng Gao, Xiaobo Wang, Zixin Deng, Xianli Meng*, Yuling Xiao^*, Seung Kim Jong^* and Xuechuan Hong^*. Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics. Chemical Reviews, 2022, 122, 1, 209–268. (co-first author)

[8] Qihang Ding, Xiaoyu Xu, Yang Li, Baoping Li, Qimanguli Saiding, Meijia Gu,* Wei Tao,* Ben Zhong Tang,* and Jong Seung Kim*. Diverse interactions between AIEgens and biomolecules/organisms: Advancing from strategic design to precision theranostics. Chem 2024, 10, 2031-2073. (co-first author)

[9] Xue Qiao, Yang Li, Wumei Wang, Tian Tian, Wuyue Su, Xiaobo Wang, Haibin Luo, Deliang Chen,* Xianli Meng,* Xiaodong Zeng,* Xuechuan Hong.* A near-infrared IIb fluorophore for in vivo imaging and image-guided therapy of ischemic stroke. Dyes and Pigments, 2023, 212, 111123. (co-first author)

授权专利

获批授权中国发明专利4件

1. ZL202110115536.8，可调控代谢的有机荧光小分子化合物及其制备方法和应用

2. ZL202110115537.2，可在体内长时间循环的有机荧光小分子化合物及其制备

3. ZL202110748816.2，具有聚集诱导发光性质的近红外二区荧光化合物及其制备方法和应用

4. ZL202110749756.6，1500 nm以上发射荧光的有机荧光小分子化合物的制备和应用