制药系
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龙思会,博士,教授

地址:中国.湖北.武汉.东湖新技术开发区光谷一路206号,武汉工程大学化工与制药学院

邮编:430205

Email:sihuilong@wit.edu.cn; 1738054890@qq.com

电话:17762502329

教育背景

2000 - 2006 美国肯塔基大学化学系(Department of Chemistry, University of Kentucky),博士

1997 - 2000 武汉大学化学系,硕士

1993 – 1997 武汉大学化学系,学士

工作履历

2014.1- 武汉工程大学化工与制药学院,特聘教授, 教授

2012-2013 美国俄亥俄州立大学化学与生物化学系(Department of Chemistry and Biochemistry, Ohio State University) 博士后

2011-2012 美国俄亥俄州立大学药学院(College of Pharmacy, Ohio State University) 博士后

2006-2011 美国肯塔基大学药学院 (College of Pharmacy, University of Kentucky) 博士后

学术兼职

美国化学会(ACS)和美国药剂科学家协会(AAPS)会员

研究领域

药物化学:抗肿瘤药物的设计,合成(design, synthesis and evaluation of anticancer drugs);抗生素类药物的设计,合成(design, synthesis and evaluation of antibiotics);天然多肽的模拟(peptidomimicry)

药物制剂:药物分子的多晶型(polymorphism of APIs),预制剂(preformulation), 药物输送体系(drug delivery systems)

有机化学:有机合成(organic synthesis)

代表性论文(专利,专著)

2025

Chen, H.; Zhang, B.; Chen, S.; Xiong, F.; Zhu, X.; Yu, B.; Long, S. Recent advances in transition metal-mediated/catalyzed radiofluorination of arenes and heteroarenes for positron emission tomography” Bioorganic Chemistry 2025 ASAP

Rehman, M. U.; Zuo, Y.; Tu, N.; Guo, J.; Liu, Z.; Cao, S.; Long, S. Diverse pharmacological activities of β-carbolines: Substitution patterns, SARs and mechanisms of action” European Journal of Medicinal Chemistry 2025, 287, 117350

Rehman, M. U.; He, F.; Shu, X.; Guo, J.; Liu, Z.; Cao, S.; Long, S. Antibacterial and antifungal pyrazoles based on different construction strategies” European Journal of Medicinal Chemistry 2025, 282, 117081

2024

Gao, Y.; Cui, J.; Cao, S.; Guo, J.; Liu, Z.; Long, S. Recent advances in peptoids as promising antimicrobial agents to target diverse microbial species” European Journal of Medicinal Chemistry 2024, 280, 116982

Cui, J.; Gao, W.; Liu, Z.; Cao, S.; Long, S. Anticancer α-, γ-, and δ-carboline derivatives: structures, mechanisms of action, and SARs” European Journal of Medicinal Chemistry Reports 2024, 12, 100221

Rehman, M. U.; Long, S.Progress and challenges in the development of triazole antimicrobials” Future Medicinal Chemistry 2024,16(23), 2451-2453

Li, J.; Li, X.; Wu, K.; Long, S.; Zhao, Y.; Jin, X.; Zhang, M.; Wu, X.; Huang, Z.; Zhou, Z.; Liu, J.; Liu, B. ”Predicting Drug‑Drug Interactions Involving Rifampicin Using a Semi‑mechanistic Hepatic Compartmental Model” Pharmaceutical Research 2024, 41, 699-709

Liu, C.; Chen, H.; Cao, S.; Guo, J.; Liu, Z.; Long, S. “RNA-binding MSI proteins and their related cancers: A medicinal chemistry perspective”, Bioorganic Chemistry 2024, 143, 107044

2023

Zhu, J.; Dai, Q.; Zhu, R.; Long, S.; Yu, W. “Advances in research on drugs for treatment of COVID-19”, Progress in Pharmaceutical Sciences 2023, 47(7), 519-531

Hu, Y.; Liu, Z.; Zha, G.; Long, S.; Sridhara, M. B.; Kumar, K. S. S.; Rakesh, K. P. “Triazole derivatives as potential antifungal agents: A structure-activity relationship (SAR) study” Process Biochemistry 2023, 135, 102–118

86. Gao, W.; Li, Y.; Zhoujin, Y.; Zeng, Q.; Fang, L.; Parkin, S.; Li, T.; Ruan, S.; Long, S. “A peptoid-like approach led to lactam-lactam dimer formation in 2-hydroxy-N-alkyl-N-phenyl-nicotinamides and their polymorphism and solvatomorphism” ACS Omega, 2023, 8, 45447−45456

Wang, J.; Long, S.; Liu, Z.; Rakesh, K. P.; Verma, R.; Verma, S. K.; Kumar, K. S. S. “Structure-activity relationship studies of thiazole agents with potential anti methicillin-resistance Staphylococcus aureus (MRSA) activity” Process Biochemistry 2023, 132, 13-29

Chen, S.; Cui, J.; Chen, H.; Yu, B.; Long, S. “Recent progress in degradation of membrane proteins by PROTACs and alternative targeted protein degradation techniques” European Journal of Medicinal Chemistry, 2023, 262, 115911

Liu, X.; Cui, J.; Zeng, Q.; Fang, L.; Liang, P-Y.; Zhou, P-P.; Parkin, S.; Li, T.; Ruan, S.; Long, S. “Solvatomorphism and first-time observation of acid-acid catemer in 4-phenylamino-benzoic acids” RSC Advances, 2023, 13, 21021-21035

Tian, G.; Song, Q.; Liu, Z.; Guo, J.; Cao, S.; Long, S. “Recent advances in 1,2,3- and 1,2,4-triazole hybrids as antimicrobials and their SAR: A critical review” European Journal of Medicinal Chemistry, 2023,259, 115603

Zhu, J.; Chen, S.; Liu, Z.; Guo, J.; Cao, S.; Long, S. “Recent advances in anticancer peptoids” Bioorganic Chemistry 2023, 139, 106686

Li, Y.; Tao, Y.; Zhoujin, Y.; Zhao, F.; Liang, P-Y.; Parkin, S.; Li, T.; Zhou, P-P.; Long, S “π–π stacking in the polymorphism of 2-(naphthalenylamino)-nicotinic acids and a comparison with their analogues” CrystEngComm, 2023, 25, 432–443

Zhoujin, Y.; Li, Y.; Liang, P-Y.; Zhou, P-P.; Parkin, S.; Li, T.; Yu, F.; Long, S. “anti/gauche Conformations lead to the polymorphism in homologous phenylalkylamino-nicotinic acids” Crystal Growth & Design 2023, 23, 3154-3163

2022

Li, J.; Wu, K.; Li, X.; Long, S.; Zhou, Z.; Zhao, Y.; Jia, R.; Song, P.; Liu, J.; Liu, B. “Quantifying induction/inhibition effects on fuzuloparib using a Physiologically Based Pharmaco-Kinetic (PBPK) model” Journal of Clinical and Experimental Pathology 2022, 105(1), 229

Zhu, R.; He, Q.; Li, Z.; Ren, Y.; Liao, Y.; Zhang, Z.; Dai, Q.; Wan, C.; Long, S.; Kong, L.; Fan, W.; Yu, W. “ROS-cleavable diselenide nanomedicine for NIR-controlled drug release and on-demand synergistic chemo-photodynamic therapy” Acta Biomaterialia, 2022, 153(22), 442

Zhao, X.; Liu, Z.; Liu, H.; Guo, J.; Long, S. “Hybrid molecules based on caffeic acid as potential therapeutics: A focused review” European Journal of Medicinal Chemistry, 2022, 243, 114745

Zhoujin, Y.; Li, Y.; Liang, P.-Y.; Zhou, P.-P.; Parkin, S.; Li, T.; Yu, F.; Long, S. “Effect of homologation on the polymorphism of anthranilic acids”, Crystal Growth & Design, 2022, 22(10), 6207

Dong, B.; Liu, Y.; Yang, P.; Sang, D.; Tian, J.; Li, L.; Long, S. “Denitrogenative cleavage of benzotriazoles and benzotriazinones, and selective N-desulfonylation of benzotriazoles by aluminum halides”, Tetrahedron Letters, 2022, 103,153965

Xie, D.; Xu, X.; Long, S.; Tang, X-Y.; Wang, L. “Synthesis of (2-(quinolin-2-yl)phenyl)carbamates by a one-pot Friedel-Crafts reaction/oxidative Umpolung Aza-Grob Fragmentation sequence” J. Org. Chem. 2022, 87(12), 7852

Tao, Y.; Liu, X.; Zhoujin, Y.; Zhou, P.-P.; Parkin, S.; Li, T.; Guo, J.; Yu, F.; Long, S. “Conformational flexibility and substitution pattern lead to polymorphism of 3-methyl-2-(phenylamino)benzoic acid” CrystEngComm, 2022, 24, 3217

Zhoujin, Y.; Li, Y., Zhang, M.; Parkin, S.; Guo, J.; Li, T.; Yu, F.; Long, S. “Polymorphism and cocrystal salt formation of 2-((2,6-dichlorophenyl)amino)benzoic acid, harvest of a second form of 2-((2,6-dimethylphenyl)amino)benzoic acid, and isomorphism between the two systems” CrystEngComm 2022, 24, 681

Zhoujin, Y.; Tao, Y.; Zhou, P.; Parkin, S. R.; Li, T.; Guo, J.; Yu, F.; Long, S.Double substitution leads to a highly polymorphic system in 5-methyl-2-m-tolylamino-benzoic acidCrystEngComm, 2022, 24, 95

2021

Zhoujin, Y.; Yang, X.; Zhang, M.; Guo, J.; Parkin, S.; Li, T.; Yu, F.; Long, S.Synthon polymorphism and π-π stacking in N-phenyl-2-hydroxynicotinanilidesCrystal Growth & Design, 2021, 21, 6155

Ren,Y.; Li, S.; Zhu, R.; Wan, C.; Song, D.; Zhu, J.; Cai, G.; Long, S.; Kong, L. Yu, W. “Discovery of STAT3 and Histone Deacetylase (HDAC) dual-pathway inhibitors for the treatment of solid cancer”,J. Med. Chem, 2021,11, 7468

Zhoujin, Y.; Zhang, M.; Parkin, S.; Li, T.; Yu, F.; Long, S. “A new solvate of clonixin and a comparison of the two clonixin solvates”, RSC Advances, 2021, 11, 24836

2020

Liu, H.; Yang, X.; Chen, J.; Zhang, M.; Parkin, S.; Cao, S.; Li, T.; Yang, Z.; Yu, F.; Long, S. Steric effect determines the formation of lactam-lactam dimer or amide C=O...NH (lactam) chain motif in N-phenyl-2-hydroxynicotinanilidesCryst. Growth Des. 2020, 20, 4346

Liu, H.; Yang, X.; Wu, S. Zhang, M.; Parkin, S.; Cao, S.; Li, T.; Yu, F.; Long, S. “An investigation of the polymorphism of a potent nonsteroidal anti-inflammatory drug flunixinCrystEngComm 2020, 22, 448

Liu, H.; Long, S.; Rakesh, K. P.; Zha, G.-F. “ Structure-activity relationships (SAR) of triazine derivatives: Promising antimicrobial agentsEuropean Journal of Medicinal Chemistry, 2020, 185, 111804

2019

Liu, H.; Moku, B.; Li, F.; Ran, J.; Han, J.; Long, S.; Zha, G.-F.; Qin, H.-L. “Stereoselective construction of nitrile-substituted cyclopropanes from 2-substituted ethenesulfonyl fluorides via carbon-sulfur bond cleavageAdvanced Synthesis & Catalysis, 2019, 361(19), 4596

Liu, Y.; Zhang, M.; Xu, D.; Parkin, S.; Li, T.; Li, C.; Yang, Z.; Yu, F.; Long, S.Effect of substituent size and isomerization on the polymorphism of 2-(naphthalenylamino)-benzoic acidsCrystal Growth & Design, 2019, 19(7), 3694

Zha, G.-F.; Rakesh, K. P.; Manukuma, H. M.; Shantharam, C. S.; Long, S. “Pharmaceutical significance of azepane based motifs for drug discovery: A critical review” European Journal of Medicinal Chemistry, 2019, 162, 465

学生获奖

2014 “海普瑞杯第四届全国学生制药工程研究征文比赛 二等奖 (指导教师)

2015 “海普瑞杯第五届全国学生制药工程研究征文比赛 二等奖 (指导教师)

2016 第九届药苑论坛 三等奖 (指导教师)

2017 研究生刘梦获第七届全国学生制药工程研究征文比赛 一等奖 (指导教师)

国家奖学金2016 陈朋;2017 刘梦;2018 乐鹏云;2019 刘浩; 2020 杨星;2021 周金韵萍;2024 崔景亮

特等学业奖学金2018 彭思情

化工与制药学院学术之星2019 乐鹏云、彭思情

优秀毕业研究生2018 刘梦;2019 彭思情;2020 刘浩;2022 周金韵萍2024 陈思宇

校优秀硕士学位论文2017 毛腾飞;2018 刘梦;2019乐鹏云; 2020 刘浩;2021 杨星2022 周金韵萍、陶洋、谢东2023 赵雪、黎玉萍、董冰倩2024 胡月潇、王静

2020刘浩被美国南卡罗来纳大学全额奖学金录取为博士研究生

2022 周金韵萍被美国明尼苏达大学全额奖学金录取为博士研究生

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