制药系
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龙姣,博士,讲师,硕士生导师

地址: 湖北省武汉市东湖新技术开发区光谷一路206号

邮编:430205

E-mail: longjiao@wit.edu.cn

教育背景

2018/09-2021/06,武汉大学,高等研究院,化学,博士(导师:阴国印 教授)

2015/09-2018/06,武汉大学,化学与分子科学学院,有机化学,硕士(导师:张绪穆 教授)

2011/09-2015/06,南昌大学,化学学院,应用化学,学士

工作履历

2023/09-至今,武汉工程大学,化工与制药学院,讲师

2021/07-2023/08,武汉大学,高等研究院,博士后(合作导师:阴国印 教授)

研究领域

不对称催化及药物合成化学

科研项目

1. 湖北省自然科学基金青年项目,基于烯烃迁移氢官能团化反应的手性胺类药物合成新策略(2024AFB233),8万元,主持。

2. 武汉工程大学科学基金,5万元,主持。

3. 武汉大学2022年大型仪器设备开放补贴,LF20221537,1.5万元,主持。

4. 中央高校基本科研业务费专项资金青年教师资助项目,迁移的非活化C(sp3)-H键硼化反应研究(2042022kf1023),5万元,主持。

5. 中国博士后科学基金面上项目,镍催化的烯烃不对称迁移碳硼化反应研究(2021M702519),8万元,主持。

学术成果

代表性论文:

1. Mu-Zi Nie, Shuang-Shuang Zhang, Shuang-Xi Gu*, Jiao Long*,Yuan-Yuan Zhu*. Advances in Diarylpyrimidines and Related Analogues as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors (2019-2023). Eur. J. Med. Chem. 2024, 280, 116973.

2. Jiao Long*, Baixue, Liu, Shuang-Shuang Zhang, Yuan-Yuan Zhu, Shuang-Xi, Gu*. Recent Advances in Nickel-Catalyzed Asymmetric Hydrofunctionalization of 1,3-Dienes. Chin. J. Org. Chem. 2024, 44, DOI: 10.6023/cjoc202403021. (in Chinese).

3. Jiao Long, Yangyang Li, and Guoyin Yin*. Hydrometallation of C-C π-bonds Followed by Cross-coupling. Comprehensive Organic Synthesis 3rd Edition, 2023, accepted manuscript.

4. Yangyang Li, Jiao Long, and Guoyin Yin*. Recent Advances in Nickel-Catalyzed C-C Cross-Coupling. Top. Organomet. Chem. 2023, 93, 181-232.

5. Jiao Long, Chao Ding and Guoyin Yin*. Nickel/Brønsted Acid Dual-catalyzed Regioselective C-H Bond Allylation of Phenols with 1,3-Dienes. Org. Chem. Front. 2022, 9, 3834-3839.

6. Jiao Long, Yuqiang Li, Weining Zhao* and Guoyin Yin*. Nickel/Brønsted Acid Dual-Catalyzed Regio- and Enantioselective Hydrophosphinylation of 1,3-Dienes: Access to Chiral Allylic Phosphine Oxides. Chem. Sci. 2022, 13, 1390-1397.

7. Jiao Long, Peng Wang, Wang Wang, Yuqiang Li and Guoyin Yin*. Nickel/Bronsted Acid-Catalyzed Chemo- and Enantioselective Intermolecular Hydroamination of Conjugated Dienes. iScience 2019, 22, 369-379.

8. Jiao Long, Liyang Shi, Xiong Li, Hui Lv* and Xumu Zhang*. Rhodium-Catalyzed Highly Regio- and Enantioselective Hydrogenation of Tetrasubstituted Allenyl Sulfones: An Efficient Access to Chiral Allylic Sulfones. Angew. Chem. Int. Ed. 2018, 57, 13248-13251.

9. Jiao Long, Wenchao Gao, Yuqing Guan, Hui Lv* and Xumu Zhang. Nickel-Catalyzed Highly Enantioselective Hydrogenation of β-Acetylamino Vinylsulfones: Access to Chiral β-Amido Sulfones. Org. Lett. 2018, 20, 5914-5917.

10. Jianfei Yu, Jiao Long (co-first author), Yuhong Yang, Weilong Wu, Peng Xue, Lung Wa Chung*, Xiu-Qin Dong* and Xumu Zhang*. Iridium-Catalyzed Asymmetric Hydrogenation of Ketones with Accessible and Modular Ferrocene-Based Amino-phosphine Acid (f-Ampha) Ligands. Org. Lett. 2017, 19, 690-693.

11. Chao Ding, Yaoyu Ren, Caocao Sun, Jiao Long, and Guoyin Yin*. Regio- and Stereoselective Alkylboration of Endocyclic Olefins Enabled by Nickel Catalysis. J. Am. Chem. Soc. 2021, 143, 20027-20034.

12. Haoyang Li, Jiao Long, Yuqiang Li, Wang Wang, Hailiang Pang and Guoyin Yin*. Nickel-Catalyzed Regioselective Arylboration of Conjugated Dienes. Eur. J. Org. Chem. 2021, 1424-1428.

专利:

一种高化学及立体选择性制备手性烯丙基胺类化合物的方法,阴国印,龙姣,王鹏,专利号:ZL 2019 1 0886513.X

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