杨泽堃，博士，校聘教授

地址：湖北省武汉市东湖新技术开发区光谷一路206号

邮编：430205

Email：zekun.yang@wit.edu.cn

教育背景

2014/09－2020/09，东京大学，大学院药学系研究科，药科学，博士（导师：内山真伸 教授）

2010/09－2014/07，复旦大学，药学院，药学，学士

工作履历

2025/08－至今，武汉工程大学，化工与制药学院，校聘教授

2024/08－2025/12，日本理化学研究所，特别研究员 (合作导师：侯召民 主任研究员)

2021/04－2024/07，第一三共株式会社，制药技术本部，研究员

2020/10－2021/03，东京大学大学院药学系研究科，JSPS特别研究员（合作导师：内山真伸 教授）

研究领域

有机合成方法学

药物合成工艺

科研项目

1.武汉工程大学科学基金，主持

2.江苏省自然科学基金青年基金，主持

3.Grant-in-Aid for JSPS Fellows (18J21229)，主持

奖励与荣誉

2024/12 国家级海外高层次青年人才计划

2020/04 国家优秀自费留学生奖学金

2018/10 大津会议会员

2018/04–2020/09 日本学术振兴会特別研究员 (JSPS-DC1)

2015/09–2017/08 东京大学奖学金

学术成果

代表性论文：

1.He, Yuan-Yuan⁺; Yang, Ze-Kun⁺; Matsuyama, Taro; Wei, Yi^*; Qin, Lan; Zhang, Zhihan^*; Uchiyama, Masanobu^*; Hu, Xiao-Qiang^*. Electronically Mismatched α-Addition of Electron-Deficient Alkenes via Photoinduced Polarity Transduction. Organic Letters, 2025, 27, 4170–4175.

2.Zhao, Yunyi; Yang, Zekun; Wang, Xin; Kang, Qinchun; Wang, Bobo; Wu, Tianle; Lei, Hao; Ma, Peile; Su, Wenqiang; Wang, Siyuan; Wu, Zhiqiang; Huang, Xinsong; Fan, Chunying^*; Wei, Xiaofeng^*. Mechanochemical Synthesis of α-Halo Alkylboronic Esters. Advanced Science, 2024, 11, 2404071.

3.Yang, Ze-Kun⁺; Xu, Ning-Xin⁺; Wang, Chao^*; Uchiyama, Masanobu^*. Photo-Induced C(sp³)-N Bond Cleavage Leading to Stereoselective Syntheses of Alkenes. Chemistry – A European Journal, 2019, 25, 5433–5439.

4.Yang, Ze-Kun; Xu, Ning-Xin; Takita, Ryo; Muranaka, Atsuya; Wang, Chao^*; Uchiyama, Masanobu^*. Cross-Coupling Polycondensation via C–O or C–N Bond Cleavage. Nature Communications, 2018, 9, 1587.

5.Wang, Dong-Yu; Yang, Ze-Kun; Wang, Chao^*; Zhang, Ao^*; Uchiyama, Masanobu^*. From Aniline to Aryl Ether: A Facile, Efficient and Versatile Synthetic Protocol Employing Mild Conditions. Angewandte Chemie International Edition, 2018, 57, 3641–3645.

6.Yang, Ze-Kun; Wang, Chao^*; Uchiyama, Masanobu^*. DFT Studies Provide Mechanistic Insight into Nickel-Catalyzed Cross-Coupling Involving Organoaluminum-Mediated C–O Bond Cleavage. Synlett, 2017, 28, 6696–6699.

7.Wang, Dong-Yu⁺; Morimoto, Koki⁺; Yang, Ze-Kun⁺; Wang, Chao^*; Uchiyama, Masanobu^*. Organozinc-Mediated Direct C–C Bond Formation via C–N Bond Cleavage of Ammonium Salt. Chemistry – An Asian Journal, 2017, 12, 2554–2557.

8.Kojima, Kumiko; Yang, Ze-Kun; Wang, Chao^*; Uchiyama, Masanobu^*. Ethereal C–O Bond Cleavage Mediated by Ni(0)-Ate Complex: A DFT Study. Chemical & Pharmaceutical Bulletin, 2017, 65, 862–868.

9.Ogawa, Hiroyuki⁺; Yang, Ze-Kun⁺; Kojima, Kumiko; Minami, Hiroki; Saito, Tatsuo; Wang, Chao^*; Uchiyama, Masanobu^*. Revisit of Organoaluminum Reagents Affords a Versatile Protocol for the C–X (X = N, O, F) Bond-Cleavage Cross-Coupling: A Systematic Study. ACS Catalysis, 2017, 7, 3988–3994.

10.Yang, Ze-Kun; Wang, Dong-Yu; Minami, Hiroki; Ogawa, Hiroyuki; Ozaki, Takashi; Saito, Tatsuo; Miyamoto, Kazunori; Wang, Chao^*; Uchiyama, Masanobu^*. Cross-Coupling of Organolithium with Ethers or Aryl Ammonium Salts by C–O or C–N Bond Cleavage. Chemistry – A European Journal, 2016, 22, 15693–15699.

11.Wang, Dong-Yu; Kawahata, Masatoshi; Yang, Ze-Kun; Miyamoto, Kazunori; Komagawa, Shinsuke; Yamaguchi, Kentaro; Wang, Chao^*; Uchiyama, Masanobu^*. Stille Coupling via C–N Bond Cleavage. Nature Communications, 2016, 7, 12937.

专利：

1.WO 2023/074843A1, Novel Oligosaccharide, manufacturing intermediate for novel oligosaccharide, and method for manufacturing these

2.ZL 202410849627.8，α-卤烷基硼酯的机械化学合成方法