薛亚楠，博士，副教授，硕士生导师

地址：中国.湖北.武汉.东湖新技术开发区光谷一路206号

武汉工程大学化工与制药学院

邮编：430205

Email：xueyn_wit@163.com

电话：027-87194980

教育背景

2003 – 2009 武汉大学化学与分子科学学院，高分子化学与物理专业，博士

1999 – 2003 郑州大学化学系，化学人才基地班，学士

工作履历

2011至今 武汉工程大学化工与制药学院，副教授

2009 – 2011 武汉大学生命科学学院，博士后

研究领域

生物医用高分子材料；

靶向多功能纳米材料。

承担或参与科研项目

1. 有序平行交联纳米凝胶复合生物材料的合成，2012FFA100，湖北省自然科学基金重点项目，2012-2014，项目骨干。

2. 还原裂解聚阳离子胶束共输送基因和抗癌药物研究，20100471143，中国博士后科学基金会，2010-2011，项目负责人。

3. 增溶与促透性纳米给药系统，2009CB930301，国家重大发展计划973项目子课题，2009-2011，课题负责人。

学术成果

代表性论文：

1. Yanan Xue, Lijun Tao, Yang Zhou, Jie Liu, Bo Yu, Sihui Long, Shiwen Huang, Faquan Yu*. Enhanced targeted delivery of doxorubicin based on acid induced charge reversal and combinational stimuli-responsive nanocarrier. Advanced Engineering Materials, 2018,20(7):1701151. .

2. Yanan Xue, Xiaoyang Xia, Bo Yu, Lijun Tao, Qian Wang, Shi-Wen Huang, Faquan Yu*. Selenylsulfide bond-launched reduction-responsive superparamagnetic nanogel combined of acid-responsiveness for achievement of efficient therapy with low side effect. ACS Applied Materials & Interfaces, 2017, 9, 30253-30257.

3. Meifang Song, Yanan Xue, Xiao Lin, Xiaoyang Xia, Lidi Chen, Liujie Zhang, Bo Yu, Sihui Long, Shiwen Huang, Faquan Yu*. Achievement of release mode under combinational stimuli by acid and reduction for reduced adverse effect in antitumor efficacy. Macromolecular Materials and Engineering. 2016,301(10): 1255-1266.

4. Meifang Song, Yanan Xue, Lidi Chen, Xiaoyang Xia, Yang Zhou, Lei Liu, Bo Yu, Sihui Long, Shiwen Huang, Faquan Yu*. Acid and reduction stimulated logic “and”-type combinational release mode achieved in DOX-loaded superparamagnetic nanogel. Materials Science & Engineering C, 2016,65:354-363.

5. Han Zhang, Yanan Xue, Juan Huang, Xiaoyang Xia, Meifang Song, Kaikai Wen, Xiaoxiao Zhang, Xiaogang Luo, Ning Cai, Sihui Long, Faquan Yu*. Tailor-made magnetic nanocarriers with pH-induced charge reversal and pH-responsiveness to guide subcellular release of doxorubicin. Journal of Materials Science, 2015, 50(6): 2429-2442.

6. Lidi Chen, Yanan Xue, Xiaoyang Xia, Meifang Song, Juan Huang, Han Zhang, Bo Yu, Sihui Long, Yanping Liu, Lei Liu, Shiwen Huang, Faquan Yu*. A redox stimuli-responsive superparamagnetic nanogel with chemically anchored DOX for enhanced anticancer efficacy and low systemic adverse effect. Journal of Materials Chemistry B, 2015,3(46):8949-8962.

7. Yanan Xue, Xiaoyang Xia, Bo Yu, Xiaogang Luo, Ning Cai, Sihui Long, Faquan Yu*. A green and facile method for the preparation of a pH-responsive alginate nanogel for subcellular delivery of doxorubicin. RSC Advances, 2015, 5(90):73416-73423.

8. Juan Huang, Yanan Xue, Ning Cai, Han Zhang, Kaikai Wen, Xiaogang Luo, Sihui Long, Faquan Yu*. Efficient reduction and pH co-triggered DOX-loaded magnetic nanogel carrier using disulfide crosslinking. Materials Science & Engineering C, 2015,46:41-51.

9. 薛亚楠, 张敏, 刘磊, 李文鑫, 黄世文. 侧链含咪唑取代基聚（L-天冬酰胺）高效基因载体研究. 高分子学报 2011;8:874-882. (SCI, IF 0.677)

10. Zhang M†, Xue YN†, Liu M, Zhuo RX, Huang SW*. Biocleavable polycationic micelles as highly efficient gene delivery vectors. Nanoscale Research Letters 2010; 5(11):1804-1811. (†co-first author) (SCI, IF 2.524)

11. Xue YN, Liu M, Peng L, Huang SW, Zhuo RX. Improving gene delivery efficiency of bioreducible poly(amidoamine)s via grafting with dendritic poly(amidoamine). Macromolecular Bioscience 2010;10(4):404-414.(SCI, IF 3.742)

12. Xue YN, Huang ZZ, Zhang JT, Liu M, Zhang M, Huang SW, Zhuo RX.Synthesis and self-assembly of amphiphilic poly (acrylic acid-b-DL-lactide) to form micelles for pH-responsive drug delivery. Polymer2009; 50(15): 3706-3713. (SCI, IF 3.379)

授权专利：

1. 一种pH响应性海藻酸钠纳米凝胶及其制备方法。 ZL2015104265218

2. 一种磁性还原响应性抗肿瘤药物载体的制备方法。ZL201510427070X

著作：

参与编写《化学工艺学》教材，ISSN 978-7-122-17367-6，化学工业出版社，2014年1月