龙思会， 博士， 教授
地址：中国.湖北.武汉.东湖新技术开发区光谷一路206号，武汉工程大学化工与制药学院
邮编：430205
Email：sihuilong@wit.edu.cn; 1738054890@qq.com
教育背景
2000 - 2006 美国肯塔基大学化学系（Department of Chemistry, University of Kentucky），博士
1997 - 2000 武汉大学化学系，硕士
1993 – 1997 武汉大学化学系，学士
工作履历
2014.1- 武汉工程大学化工与制药学院，特聘教授, 教授
2012-2013 美国俄亥俄州立大学化学与生物化学系(Department of Chemistry and Biochemistry, Ohio State University) 博士后
2011-2012 美国俄亥俄州立大学药学院(College of Pharmacy, Ohio State University) 博士后
2006-2011 美国肯塔基大学药学院 (College of Pharmacy, University of Kentucky) 博士后
学术兼职
美国化学会（ACS）和美国药剂科学家协会（AAPS）会员
研究领域
药物化学：抗肿瘤药物的设计，合成(design, synthesis and evaluation of anticancer drugs)；抗生素类药物的设计，合成(design, synthesis and evaluation of antibiotics)；天然多肽的模拟(peptidomimicry)
药物制剂：药物分子的多晶型(polymorphism of APIs),预制剂(preformulation), 药物输送体系(drug delivery systems)
有机化学：有机合成(organic synthesis)
学术成果
已发表SCI期刊论文100余篇,学术专著<Chronopharmacology>章节<Time-dependent Drug Responses in Oncology>
代表性论文（专利，专著）：
2025
Rehman, M. U.; Wu, X.; Chen, Q.; Liu, Z.; Long, S. Lysosome-targeting chimeras: design, mechanisms, and degradation of “rogue” proteins Bioorganic Chemistry, 2025, 167, 109429
Zhang, M.; Rehman, M. U.; Long, S. G protein-coupled receptors in drug discovery for neurological and psychiatric disorders: therapeutic targets, mechanisms, and future prospects Biochemical Pharmacology, 2025, 242, 117380
Yang, H.#; Huang, H.#; Wang, Y.; Long, S.*; Liu, Q.* Ligand-controlled stereodivergent Manganese-catalyzed hydroalkoxylation of alkynylnitriles to access (E)- and (Z)-3-alkoxyvinylnitriles Angew Chem Int Ed 2025, 137, e202511311
Zhang, K.; Xu, Z.; Xiao, Z.; Cao, F.; Wang, J.; Xu, Y.; Ma, W. M. J.; Long, S.; Zha, G. α-GalCer-LNP ehanced mRNA delivery and activation of natural killer T cells for superior tumor immunotherapy Materials Today Bio, 2025, 32, 101893
Zhang, M.; Wu, K.; Long, S.; Jin, X.; Liu, B. Prediction of pharmacokinetic/ pharmacodynamic properties of aldosterone synthase inhibitors at drug discovery stage using an artificial intelligence-physiologically based pharmacokinetic model Frontiers in Pharmacology, 10.3389/fphar.2025.1578117
Chen, H.; Zhang, B.; Chen, S.; Xiong, F.; Zhu, X.; Yu, B.; Long, S. Recent advances in transition metal-mediated/catalyzed radiofluorination of arenes and heteroarenes for positron emission tomography Bioorganic Chemistry, 2025,157, 108272
Rehman, M. U.; Zuo, Y.; Tu, N.; Guo, J.; Liu, Z.; Cao, S.; Long, S. Diverse pharmacological activities of β-carbolines: substitution patterns, SARs and mechanisms of action European Journal of Medicinal Chemistry, 2025, 287, 117350
Rehman, M. U.; He, F.; Shu, X.; Guo, J.; Liu, Z.; Cao, S.; Long, S. Antibacterial and antifungal pyrazoles based on different construction strategies European Journal of Medicinal Chemistry, 2025, 282, 117081
2024
Gao, Y.; Cui, J.; Cao, S.; Guo, J.; Liu, Z.; Long, S. Recent advances in peptoids as promising antimicrobial agents to target diverse microbial species European Journal of Medicinal Chemistry, 2024, 280, 116982
Cui, J.; Gao, W.; Liu, Z.; Cao, S.; Long, S. Anticancer α-, γ-, and δ-carboline derivatives: structures, mechanisms of action, and SARs European Journal of Medicinal Chemistry Reports, 2024, 12, 100221
Rehman, M. U.; Long, S. Progress and challenges in the development of triazole antimicrobials Future Medicinal Chemistry, 2024,16(23), 2451-2453
Li, J.; Li, X.; Wu, K.; Long, S.; Zhao, Y.; Jin, X.; Zhang, M.; Wu, X.; Huang, Z.; Zhou, Z.; Liu, J.; Liu, B. Predicting drugdDrug interactions involving Rifampicin ssing a semi mechanistic hepatic compartmental model Pharmaceutical Research, 2024, 41, 699-709
Liu, C.; Chen, H.; Cao, S.; Guo, J.; Liu, Z.; Long, S. RNA-binding MSI proteins and their related cancers: a medicinal chemistry perspective Bioorganic Chemistry, 2024, 143, 107044
2023
Hu, Y.; Liu, Z.; Zha, G.; Long, S.; Sridhara, M. B.; Kumar, K. S. S.; Rakesh, K. P. Triazole derivatives as potential antifungal agents: a structure-activity relationship (SAR) study Process Biochemistry, 2023, 135, 102–118
86. Gao, W.; Li, Y.; Zhoujin, Y.; Zeng, Q.; Fang, L.; Parkin, S.; Li, T.; Ruan, S.; Long, S. A peptoid-like approach led to lactam-lactam dimer formation in 2-hydroxy-N-alkyl-N-phenyl-nicotinamides and their polymorphism and solvatomorphism ACS Omega, 2023, 8, 45447−45456
Wang, J.; Long, S.; Liu, Z.; Rakesh, K. P.; Verma, R.; Verma, S. K.; Kumar, K. S. S. Structure-activity relationship studies of thiazole agents with potential anti methicillin-resistance Staphylococcus aureus (MRSA) activity Process Biochemistry 2023, 132, 13-29
Chen, S.; Cui, J.; Chen, H.; Yu, B.; Long, S. Recent progress in degradation of membrane proteins by PROTACs and alternative targeted protein degradation techniques European Journal of Medicinal Chemistry, 2023, 262, 115911
Liu, X.; Cui, J.; Zeng, Q.; Fang, L.; Liang, P-Y.; Zhou, P-P.; Parkin, S.; Li, T.; Ruan, S.; Long, S. Solvatomorphism and first-time observation of acid-acid catemer in 4-phenylamino-benzoic acids RSC Advances, 2023, 13, 21021-21035
Tian, G.; Song, Q.; Liu, Z.; Guo, J.; Cao, S.; Long, S. Recent advances in 1,2,3- and 1,2,4-triazole hybrids as antimicrobials and their SAR: a critical review European Journal of Medicinal Chemistry, 2023,259, 115603
Zhu, J.; Chen, S.; Liu, Z.; Guo, J.; Cao, S.; Long, S. Recent advances in anticancer peptoids Bioorganic Chemistry, 2023, 139, 106686
Li, Y.; Tao, Y.; Zhoujin, Y.; Zhao, F.; Liang, P-Y.; Parkin, S.; Li, T.; Zhou, P-P.; Long, S π–π stacking in the polymorphism of 2-(naphthalenylamino)-nicotinic acids and a comparison with their analogues CrystEngComm, 2023, 25, 432–443
Zhoujin, Y.; Li, Y.; Liang, P-Y.; Zhou, P-P.; Parkin, S.; Li, T.; Yu, F.; Long, S. anti/gauche Conformations lead to the polymorphism in homologous phenylalkylamino-nicotinic acids Crystal Growth & Design, 2023, 23, 3154-3163
2022
Zhu, R.; He, Q.; Li, Z.; Ren, Y.; Liao, Y.; Zhang, Z.; Dai, Q.; Wan, C.; Long, S.; Kong, L.; Fan, W.; Yu, W. ROS-cleavable diselenide nanomedicine for NIR-controlled drug release and on-demand synergistic chemo-photodynamic therapy Acta Biomaterialia, 2022, 153(22), 442
Zhao, X.; Liu, Z.; Liu, H.; Guo, J.; Long, S. Hybrid molecules based on caffeic acid as potential therapeutics: a focused review European Journal of Medicinal Chemistry, 2022, 243, 114745
Zhoujin, Y.; Li, Y.; Liang, P.-Y.; Zhou, P.-P.; Parkin, S.; Li, T.; Yu, F.; Long, S. Effect of homologation on the polymorphism of anthranilic acids, Crystal Growth & Design, 2022, 22(10), 6207
Dong, B.; Liu, Y.; Yang, P.; Sang, D.; Tian, J.; Li, L.; Long, S. Denitrogenative cleavage of benzotriazoles and benzotriazinones, and selective N-desulfonylation of benzotriazoles by aluminum halides Tetrahedron Letters, 2022, 103,153965
Xie, D.; Xu, X.; Long, S.; Tang, X-Y.; Wang, L. Synthesis of (2-(quinolin-2-yl)phenyl)carbamates by a one-pot Friedel-Crafts reaction/oxidative Umpolung Aza-Grob Fragmentation sequence J. Org. Chem., 2022, 87(12), 7852
Tao, Y.; Liu, X.; Zhoujin, Y.; Zhou, P.-P.; Parkin, S.; Li, T.; Guo, J.; Yu, F.; Long, S. Conformational flexibility and substitution pattern lead to polymorphism of 3-methyl-2-(phenylamino)benzoic acid CrystEngComm, 2022, 24, 3217
Zhoujin, Y.; Li, Y.; Zhang, M.; Parkin, S.; Guo, J.; Li, T.; Yu, F.; Long, S. Polymorphism and cocrystal salt formation of 2-((2,6-dichlorophenyl)amino)benzoic acid, harvest of a second form of 2-((2,6-dimethylphenyl)amino)benzoic acid, and isomorphism between the two systems CrystEngComm, 2022, 24, 681
Zhoujin, Y., Tao, Y., Zhou, P., Parkin, S. R., Li, T., Guo, J., Yu, F., Long, S. Double substitution leads to a highly polymorphic system in 5-methyl-2-m-tolylamino-benzoic acid CrystEngComm, 2022, 24, 95
2021
Zhoujin, Y.; Yang, X.; Zhang, M.; Guo, J.; Parkin, S.; Li, T.; Yu, F.; Long, S. Synthon polymorphism and π-π stacking in N-phenyl-2-hydroxynicotinanilides Crystal Growth & Design, 2021, 21, 6155
Ren,Y., Li, S.; Zhu, R.; Wan, C.; Song, D.; Zhu, J.; Cai, G.; Long, S.; Kong, L., Yu, W. Discovery of STAT3 and Histone Deacetylase (HDAC) dual-pathway inhibitors for the treatment of solid cancer J. Med. Chem., 2021,11, 7468
Zhoujin, Y.; Zhang, M.; Parkin, S.; Li, T.; Yu, F.; Long, S. A new solvate of clonixin and a comparison of the two clonixin solvates RSC Advances, 2021, 11, 24836
学生获奖
2017 研究生刘梦获第七届全国学生制药工程研究征文比赛 一等奖 （指导教师）
国家奖学金：2016 陈朋；2017 刘梦；2018 乐鹏云；2019 刘浩； 2020 杨星；2021 周金韵萍；2024 崔景亮; 2025 张梦君
特等学业奖学金：2018 彭思情
化工与制药学院”学术之星”：2019 乐鹏云、彭思情
优秀毕业研究生：2018 刘梦；2019 彭思情；2020 刘浩；2022 周金韵萍；2024 陈思宇
校优秀硕士学位论文：2017 毛腾飞；2018 刘梦；2019乐鹏云； 2020 刘浩；2021 杨星；2022 周金韵萍、陶洋、谢东；2023 赵雪、黎玉萍、董冰倩；2024 胡月潇、王静
2020刘浩被美国南卡罗来纳大学全额奖学金录取为博士研究生
2022 周金韵萍被美国明尼苏达大学全额奖学金录取为博士研究生
2025 Muneeb Rehman被美国南卡罗来纳大学全额奖学金录取为博士研究生
