刘根炎，博士，教授，博士生导师

地址：湖北省武汉市东湖新技术开发区光谷一路206号武汉工程大学化工与制药学院大化工楼1017

Email：liugenyan@wit.edu.cn；27944219@qq.com；genyanliu@163.com

电话：+86-27-87194980

教育背景

2011 – 2016 日本Tottori University，博士（日本文部省国费奖学金资助，优秀毕业生提前毕业）

2007 – 2010 武汉工程大学化工与制药学院，硕士

2003 – 2007 武汉工程大学化工与制药学院，学士

工作履历

2016 – 至今 武汉工程大学化工与制药学院，教授（特聘教授），院长助理，教务处副处长

2010 – 2011 国家磷资源开发利用工程技术研究中心，研究助理

学术兼职

中国药学会制药工程分委会青年委员、湖北省药学会制药工程分委会委员；国家自然科学基金评审专家、教育部学位论文评审专家、教育部药学教指委核心课程师资培训授课专家、湖北省科技厅评审专家、中国化学会会员、中国药学会会员、美国化学会（ACS）会员、日本农药学会（PSSJ）会员；Journal of Agricultural and Food Chemistry, European Journal of Medicinal Chemistry, Pest Management Science, Bioorganic & Medicinal Chemistry, Journal of Chemical Information and Modeling, Chinese Chemical Letters等多个SCI期刊审稿人

研究领域

药物化学：药物分子设计、合成与筛选；药物合成工艺；计算机辅助药物设计

药理学：药物作用机制模拟；新药先导分子虚拟筛序

化学生物学：绿色农药设计与研制；配体门控离子通道电生理

招生专业：药物化学、制药化学、制药工程、药理学、药剂学、生物与医药、生物化工

学术成果

主持国家自然科学基金面上项目、国家自然科学基金青年项目、湖北省自然科学基金面上项目、湖北省教育厅科学研究计划项目和企业委托项目等10余项科研课题；主持湖北省虚拟仿真实验教学项目（省级金课）1项；参与了国家自然科学基金面上项目、湖北省重点研发计划项目、湖北省高等学校优秀中青年科技创新团队项目和企业横向等多个科研课题；担任湖北省人才办和经信厅为企业选派的“科技副总”。迄今在J Agri Food Chem、Pest Manag Sci、Eur J Med Chem、Chemosphere、Insect Biochem Mol Biol、药学学报、农药学学报等国内外学术期刊上发表SCI收录学术论文50余篇；获国家授权发明专利6项；多次在IUPAC化学国际会议、美国化学会年会、日本农药化学会年和中国化学会年会等做报告；首批国家级金课“制药工艺设计”（线下一流本科课程）主讲教师（排2）；获湖北省高等学校教学成果二等奖、第五届中国石油和化工教育学成果二等奖、武汉工程大学第九届教学成果特等奖；连续三年指导学生蝉联全国大制药工程设计竞赛全国一等奖（最高奖项）。

代表性论文（部分）：

1. Huang C, Wu Y, Zhai N, Zhao C, Luo X, Ozoe Y, Liu G*. 5-(4-Pyridinyl)-3-isothiazololsas competitive antagonists of insect GABA receptors: Design, synthesis, and anew mechanism leading to insecticidal effects. Journal of Agricultural and Food Chemistry. 2022, DOI: 10.1021/acs.jafc.1c08030.

2. Zhai N, Chen Y, Wang C, Wu F, Luo X, Liu H, Ju X, Liu G*. A multiscale screening strategy for the identification of novel xanthine oxidase inhibitors based on the pharmacological features of febuxostat analogues. New Journal of Chemistry. 2022, 46, 6549-6559.

3. Liu G*, Zhou C, Zhang Z, Wang C, Luo X, Ju X, Zhao C, Ozoe Y. Novel insecticidal 1,6-dihydro-6-iminopyridazine derivatives as competitive antagonists of insect RDL GABA receptors. Pest Management Science. 2022, DOI: 10.1002/ps.6911.

4. Li H, Wang J, Li Y, Chen X, Zhang W, Zhao Y, Liu G*, Pan J. Detection of Aβ oligomers in early Alzheimer’s disease diagnose by in vivo NIR-II fluorescence imaging. Sensors and Actuators B: Chemical. 2022, 358: 131481.

5. Zheng X, Wang C, Zhai N, Luo X, Liu G*, Ju X. In silico screening of novel α1-GABAA receptor PAMs towards schizophrenia based on combined modeling studiesof imidazo 1,2-a -pyridines. International Journal of Molecular Sciences. 2021, 22: 9645.

6. Zhai N, Wang C, Wu F, Xiong L, Luo X, Ju X, Liu G*. Exploration of novelxanthine oxidase inhibitors based on 1,6-dihydropyrimidine-5-carboxylicacids byan integrated in silico study. International Journal of Molecular Sciences. 2021, 22: 8122.

7. Wang C, Zhai N, Zhao Y, Wu F, Luo X, Ju X, Liu G*, Liu H. Exploration of novel hepatitis B virus capsid assembly modulators by integrated molecular simulations.Chemistryselect. 2021, 6: 12524-12536.

8. Liu Y, Guo Y, Luo X, Liu G*, Sun Q. Detection of metalions. small moleculesand large molecules by near-infrared fluorescent probes. Progress in Chemistry (化学进展). 2021, 33: 199-215.

9. Li H, Wang J, Zhang W, Xia Z, Zhai N, Liu G*, Wang K, Pan J. Functional bioprobe for responsive imaging and inhibition of amyloid-beta oligomer based on curcuminoid scaffold. Journal of Luminescence. 2021, 238: 118218.

10. 李文烨, 翟纳, 巨修练, 刘根炎*. 黄嘌呤氧化酶抑制剂非布司他衍生物的研究进展. 药学学报, 2021, 56: 3401-3413.

11. Liu G*, Wu Y, Gao Y, Ju X, Ozoe Y. Potential of competitive antagonists of insectionotropic γ-aminobutyric acid receptors as insecticides. Journal of Agricultural and Food Chemistry. 2020, 68: 4760-4768.

12. Gao Y, Zhang Y, Wu F, Pei J, Luo X, Ju X, Zhao C, Liu G*. Exploring theinteraction mechanism of desmethyl-broflanilide in insect GABA receptors and screening potential antagonists by in silico simulations. Journal of Agricultural and Food Chemistry. 2020, 68: 14768-14780.

13. Chen Y, Tian Y, Gao Y, Wu F, Luo X, Ju X, Liu G*. In silico design of novel HIV-1 NNRTIs based on combined modeling studies of dihydrofuro[3,4-d]pyrimidines. Frontiers in Chemistry. 2020, 8: 164.

14. Chen Y, Gao Y, Wu F, Luo X, Ju X, Liu G*. Computationally exploring novel xanthine oxidase inhibitors using docking-based 3D-QSAR, molecular dynamics,and virtual screening. New Journal of Chemistry. 2020, 44: 19276-19287.

15.艾大朋, 巨修练, 刘根炎*. 作用于离子型γ-氨基丁酸受体的异噁唑啉类杀寄生虫剂. 化学通报, 2020, 83: 986-996.

16. Wang W, Tian Y, Wan Y, Gu S, Ju X, Luo X, Liu G*. Insights into the key structural features of N-1-ary-benzimidazols as HIV-1NNRTIs using molecular docking, molecular dynamics, 3D-QSAR, and pharmacophore modeling. Structural Chemistry. 2019, 30: 385-397.

17. Tian Y, Gao Y, Chen Y, Liu G*, Ju X. Identification of the fipronil resistance associated mutations in Nilaparvata lugens GABA receptors by molecular modeling. Molecules. 2019, 24: 4116.

18. Sheng C, Huang Q, Liu G^#, Ren X, Jiang J, Jia Z, Han Z, Zhao C. Neurotoxicity and mode of action of fluralaner on honeybee Apis mellifera L. Pest Management Science. 2019, 75: 2901-2909.

19. Liu G*, Wan Y, Wang W, Fang S, Gu S, Ju X. Docking-based 3D-QSAR and pharmacophore studies on diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Molecular Diversity. 2019, 23: 107-121.

20. Liu G*, Li H, Shi J, Wang W, Furuta K, Liu D, Zhao C, Ozoe F, Ju X, Ozoe Y.4-Aryl-5-carbamoyl-3-isoxazolols as competitive antagonists of insect GABA receptors: Synthesis, biological activity, and molecular docking studies. Bioorganic&Medicinal Chemistry. 2019, 27: 416-424.

21. HuangQ, Sheng C, Jiang J, Jia Z, Han Z, Zhao C, Liu G*. Functional integrityof honeybee (Apis mellifera L.) resistant to dieldrin γ-aminobutyric acid receptor channels conjugated with three fluorescent proteins. Insect Molecular Biology. 2019, 28: 313-320.

22. Gao Y, Chen Y, Tian Y, Zhao Y, Wu F, Luo X, Ju X, Liu G*. In silico study of 3-hydroxypyrimidine-2,4-diones as inhibitors of HIVRT-associated RNase H using molecular docking, molecular dynamics, 3D-QSAR, and pharmacophore models. New Journal of Chemistry. 2019, 43: 17004-17017.

23. Wan Y, Tian Y, Wang W, Gu S, Ju X, Liu G*. In silico studies of diarylpyridine derivatives as novel HIV-1 NNRTIs using docking-based 3D-QSAR,molecular dynamics, and pharmacophore modeling approaches. RSC Advances. 2018, 8: 40529-40543.

24. Liu G*,Wang W, Wan Y, Ju X, Gu S. Application of 3D-QSAR, pharmacophore, and molecular docking in the molecular design of diarylpyrimidine derivatives as HIV-1 nonnucleoside reverse transcriptase inhibitors. International Journal of Molecular Sciences. 2018, 19: 1436.

25. Kita T, Hayashi T, Ohtani T, Takao H, Takasu H, Liu G, Ohta H, Ozoe F, OzoeY. Amitraz and its metabolite differentially activate α-and β-adrenergic-like octopamine receptors. Pest Management Science. 2017, 73: 984-990.

26.郑小娇, 李华光, 刘根炎*, 巨修练. 昆虫γ-氨基丁酸受体竞争性拮抗剂的研究进展. 农药学学报, 2017, 19: 665-671.

27. Liu G, Ozoe F, Furuta K, Ozoe Y. 4,5-Substituted 3-isoxazolols with insecticidal activitya ct as competitive antagonists of housefly GABA receptors. Journal of Agricultural and Food Chemistry. 2015, 63: 6304-6312.

28. Liu G, Frolund B, Ozoe F, Ozoe Y. Differential interactions of 5-(4-piperidyl)-3-isoxazolol analogues with insect γ-aminobutyric acid receptors leading to functional selectivity. Insect Bio chemistry and Molecular Biology. 2015, 66: 64-71.

29 Liu G, Furuta K, Nakajima H, Ozoe F, Ozoe Y. Competitive antagonism of insect GABA receptors by 4-substituted 5-(4-piperidyl)-3-isothiazolols. Bioorganic &Medicinal Chemistry. 2014, 22: 4637-4645.

30. Liu G, Ju X, Cheng J, Liu Z. 3D-QSAR studies of insecticidal anthranilic diamides as ryanodine receptor activators using CoMFA, CoMSIA and DISCOtech. Chemosphere. 2010, 78: 300-306.

31. Liu G, Ju X, Cheng J. Selectivity of Imidacloprid for fruit fly versus rat nicotinic acetylcholine receptors by molecular modeling. Journal of Molecular Modeling. 2010, 16: 993-1002.

32 Liu G, Miao W, Ju X. Mechanisms of imidacloprid resistance in Nilaparvata lugens by molecular modeling. Chinese Chemical Letters. 2010, 21: 492-495.

奖励与荣誉

[1]2019-2021年度武汉工程大学“优秀共产党员”

[2]武汉工程大学第七届“互联网+”大学生创新创业大赛金奖，2021年，指导老师

[3]武汉工程大学百佳导师、优秀班主任，2021年

[4]研究生翟纳获国家奖学金，2021年，指导老师

[5]研究生高娅和陈炎明学位论文获校优秀硕士学位论文，2021年，指导老师

[6]研究生陈炎明获优秀毕业研究生，2020年，指导老师

[7]第十届全国大学生制药工程设计作品交流会优秀作品（一等奖），2020年，指导老师

[8]第五届中国石油和化工教育教学优秀成果二等奖（排2），2020年

[9]武汉工程大学第九届教学成果特等奖（排2），2020年

[10]研究生吴贇获校优秀硕士学位论文，2020年，指导老师

[11]研究生陈炎明获国家奖学金，2019年，指导老师

[12]研究生王雯洁和万幽兰学位论文获校优秀硕士学位论文，2019年，指导老师

[13]第九届“国药工程-东富龙杯”全国大学生制药工程设计竞赛一等奖，2019年，指导老师

[14]武汉工程大学第五届“互联网+”大学生创新创业大赛二等奖，2019年，指导老师

[15]研究生王雯洁获国家奖学金，2018年，指导老师

[16]第八届“国药工程-东富龙杯”全国大学生制药工程设计竞赛一等奖，2018年，指导老师

[17]第七届“国药工程-东富龙杯”全国大学生制药工程设计竞赛二等奖，2017年，指导老师

[18]13th IUPAC AGRO EducationAwards，2014年

[19]日本文部省国费奖学金，2011年

[20]湖北省优秀硕士论文，2011年